MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that regulate a variety of biological processes such as differentiation,\ndevelopment, and survival. Recent studies suggest that miRNAs are dysregulated in cancer and play critical roles in cancer\ninitiation, progression, and chemoresistance. Therefore, exploitation of miRNAs as targets for cancer prevention and therapy\ncould be a promising approach. Extensive evidence suggests that many naturally occurring phytochemicals regulate the expression\nof numerous miRNAs involved in the pathobiology of cancer. Therefore, an understanding of the regulation of miRNAs by\nphytochemicals in cancer, their underlying molecular mechanisms, and functional consequences on tumor pathophysiology may\nbe useful in formulating novel strategies to combat this devastating disease.These aspects are discussed in this review paper with\nan objective of highlighting the significance of these observations from the translational standpoint.
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